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A complete of 3 % of Energetic substance is excreted in urine as unchanged Energetic substance. Tapentadol is additionally metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, which can be more metabolised by conjugation. Thus, Lively material metabolism mediated by cytochrome P450 syst